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Salofalk suppositories dose with the anticonvulsants carbamazepine or phenytoin is significantly decreased in the patients with type 2 diabetes mellitus treated with lamotrigine.
Clinical Pharmacology
Mechanism of Action
At higher doses, lamotrigine exert significant sedation but only a moderate reduction in AUC values, which may increase in the presence of CNS depression [see Drug Interactions (7.3)].
Mechanism of Action in Acute, Chronic, and Severe Neurologic Disorders
Mechanism of Action in Acute, chronic, and severe neurologic disorders is unknown, and no specific clinical data concerning mechanism of action for lamotrigine in acute and chronic neurologic disorders are currently available.
Mechanism of Actions in Neurologic Disorders Dizziness, Tremor, & Headache Associated with Chronic Heart Failure (DOH)
Because of adverse reactions caused by OH, patients with OH may have an increased susceptibility to developing lamotrigine syndrome or any of the anticonvulsant interactions described previously (see Drug (7.3)). Lamotrigine has been shown in preclinical models to reverse the anticonvulsant effects of OH, although the mechanism is unknown, perhaps pharmacy courses online in uk by decreasing AVP release in the brain [see Pharmacodynamics (12.3)]. Therefore, in patients with OH, a decreased seizure threshold, including possible increase in percentage seizure threshold, may be seen in some patients treated with lamotrigine, although at lower doses relative to those given for seizures (see Clinical Studies [4.8).
Mechanism of Actions in Dizziness and Tremor Associated with Parkinson's Disease
Tremor and dyskinesias associated with Parkinson's disease (PD) may be treated with lamotrigine in a manner somewhat similar to its treatment in pediatric patients. Because there have been no controlled trials in this population, the role of lamotrigine in PD (and other illnesses which antiepileptics are being considered) is not well settled.
Lam