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Best generic isotretinoin on price and efficacy" with more than 6,000 adverse reactions and more than 16,000 adverse promethazine with codeine syrup in canada patient experiences. Some were severe, had to be hospitalized, and many others had "potentially life-threatening drug interactions." The authors of BMJ review suggest that the real costs of treating acne are much higher than those in the U.S., and that if we don't figure out what's going wrong, people might experience the same kind of adverse events we see with this drug that are preventable with other, less expensive, drugs.
It is impossible for me to determine exactly how much of the $32 billion spent on acne drugs in the U.S. is unjustified. Most doctors and dermatologists, for example, feel that acne is largely preventable, and that treating it at all costs requires using very effective treatments. At this time, the FDA doesn't require companies to prove that a certain acne drug is effective, but you would think that they'd do so if they think the benefit is not worth cost. Unfortunately, this drug has no known benefit, and even though it has been around for years and FDA-approved, the safety evidence is so sketc
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